Gallium Maltolate: A Compound with High Oral Bioavailability
Author Information
Author(s): Lawrence R. Bernstein, Trevor Tanner, Claire Godfrey, Bruce Noll
Primary Institution: GeoMed, Inc.
Hypothesis
Can gallium maltolate provide a more effective oral alternative to parenterally administered gallium?
Conclusion
Gallium maltolate is well tolerated and has an estimated oral bioavailability of 25-57%, significantly higher than that of gallium salts.
Supporting Evidence
- Gallium maltolate was very well tolerated by all subjects.
- The estimated oral bioavailability of gallium from gallium maltolate is significantly higher than from gallium chloride.
- Approximately 2% of gallium from orally administered gallium maltolate is excreted in urine within 72 hours.
- The dominant elimination half-life for gallium from blood plasma for oral gallium maltolate is approximately 17 to 21 hours.
Takeaway
Gallium maltolate is a new medicine that can be taken by mouth and works better than other forms of gallium.
Methodology
The study involved administering gallium maltolate to healthy volunteers in single doses and measuring its absorption and effects.
Limitations
The study had a small sample size and was limited to healthy volunteers.
Participant Demographics
Healthy males and females aged 21 to 60, with a weight of at least 60 kg.
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