Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
2024

High Blood Pressure After Pregnancy Complications

Sample size: 7343 publication 10 minutes Evidence: high

Author Information

Author(s): Ishikuro Mami, Obara Taku, Hasegawa Mayu, Murakami Keiko, Ueno Fumihiko, Noda Aoi, Onuma Tomomi, Matsuzaki Fumiko, Iwama Noriyuki, Kikuya Masahiro, Sugawara Junichi, Azegami Tatsuhiko, Nakayama Takashin, Mito Asako, Arata Naoko, Metoki Hirohito, Kanda Takeshi, Kuriyama Shinichi

Primary Institution: Tohoku Medical Megabank Organization, Tohoku University

Hypothesis

Does a history of hypertensive disorders of pregnancy increase the risk of high blood pressure postpartum?

Conclusion

Women with a history of hypertensive disorders of pregnancy have higher blood pressure approximately three years after giving birth compared to those without such a history.

Supporting Evidence

  • Women with a history of hypertensive disorders of pregnancy had higher blood pressure approximately three years postpartum compared to normotensive women.
  • Hypertensive disorders of pregnancy were associated with an increased risk of subsequent hypertension.
  • Even one experience of hypertensive disorders of pregnancy may contribute to elevated blood pressure postpartum.

Takeaway

If a mom had high blood pressure during pregnancy, she might have high blood pressure later too, even after the baby is born.

Methodology

The study analyzed data from the Tohoku Medical Megabank Project, comparing blood pressure in women with and without a history of hypertensive disorders of pregnancy.

Potential Biases

Participants who completed follow-up assessments may have been more health-conscious, potentially underestimating blood pressure levels.

Limitations

The study could not follow all women three years postpartum, and data on hypertensive disorders and birthweight were self-reported, which may introduce recall bias.

Participant Demographics

The mean age of women with a history of hypertensive disorders was 36.2 years, and 12.4% of the participants had a history of hypertensive disorders.

Statistical Information

P-Value

p<0.0001

Confidence Interval

95% CI [4.29–7.29]

Statistical Significance

p<0.0001

Digital Object Identifier (DOI)

10.1038/s41440-024-01936-9

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