HPV Types and Risk Factors for Cervical Cancer in Peru
Author Information
Author(s): Santos C, Muñoz N, Klug S, Almonte M, Guerrero I, Alvarez M, Velarde C, Galdos O, Castillo M, Walboomers J, Meijer C, Caceres E
Primary Institution: Instituto de Enfermedades Neoplásicas ‘Dr Eduardo Cáceres Graziani'
Hypothesis
What are the HPV types and cofactors causing cervical cancer in Peruvian women?
Conclusion
HPV is the main cause of both squamous cell carcinoma and adenocarcinoma in Peruvian women.
Supporting Evidence
- HPV DNA was detected in 95.3% of women with squamous cell carcinoma.
- HPV DNA was detected in 92.0% of women with adenocarcinoma/adenosquamous carcinoma.
- Only 17.7% of control women tested positive for HPV DNA.
- The commonest HPV types found were HPV 16, 18, 31, 52, and 35.
- Long-term use of oral contraceptives was associated with increased risk.
- Smoking was also associated with an increased risk of cervical cancer.
Takeaway
This study found that HPV is a major cause of cervical cancer in women from Peru, and that other factors like smoking and long-term use of birth control can also increase risk.
Methodology
A hospital-based case-control study was conducted with interviews and PCR-based assays to detect HPV DNA.
Participant Demographics
198 women with cervical cancer and 196 control women.
Statistical Information
Confidence Interval
95% Cl = 48.6–276.0 for squamous cell carcinoma; 95% Cl = 11.4–232.0 for adenocarcinoma/adenosquamous carcinoma.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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