4-{2-[(3,4-Dichlorophenyl)(methyl)amino]-4-methyl-1,3-thiazol-5-yl}-N-(3-methylphenyl)pyrimidin-2-amine
2011
Study of a New Thiazole-Pyrimidine Compound
publication
Evidence: moderate
Author Information
Author(s): Li Hai-Bo, Shi Hai-Bo, Hu Wei-Xiao
Primary Institution: Nantong Center for Disease Control and Prevention
Hypothesis
The introduction of an arylamino group into the thiazole ring of thiazolyl-pyrimidine derivatives will affect their biological activity.
Conclusion
The crystal structure of the compound was successfully determined using single-crystal X-ray diffraction.
Supporting Evidence
- The thiazole and pyrimidine rings in the compound are almost co-planar.
- Intermolecular N—H⋯N hydrogen bonds link pairs of molecules into centrosymmetric dimers.
Takeaway
Scientists made a new chemical compound and used special X-ray techniques to see its structure.
Methodology
Single-crystal X-ray diffraction was used to determine the structure of the compound.
Limitations
The initial compound obtained was not suitable for X-ray diffraction studies.
Digital Object Identifier (DOI)
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