Creatinine-Cystatin C Ratio Predicts Mortality in Dialysis Patients
Author Information
Author(s): Z. Zhang, T. Zhou, M. Zhang, S. Cheng
Primary Institution: National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China
Hypothesis
The Cr/CysC ratio may predict all-cause mortality and technique failure in anuric peritoneal dialysis patients.
Conclusion
The Cr/CysC ratio at baseline was recognized as an independent predictor of all-cause mortality and technique failure in anuric PD patients.
Supporting Evidence
- The Cr/CysC ratio was significantly linked to the risk of all-cause mortality and technique failure.
- Patients with a high Cr/CysC ratio had lower rates of mortality and technique failure compared to those with a low ratio.
- The study included a follow-up period extending until December 31, 2023.
Takeaway
Doctors can use a simple test called the Cr/CysC ratio to help predict if patients on dialysis will live longer or have problems with their treatment.
Methodology
A cohort of 224 anuric PD patients was followed from 2014 to 2023, evaluating the Cr/CysC ratio's relationship with survival and technique failure using Cox regression and competing risk analyses.
Potential Biases
Potential residual confounding and uncontrolled variables may affect the findings.
Limitations
The study is retrospective, has a relatively small sample size, and did not analyze changes in the Cr/CysC ratio over time.
Participant Demographics
Average age was 50.46 years, with 44.2% male and the primary cause of ESKD being glomerulonephritis (82.1%).
Statistical Information
P-Value
0.027
Confidence Interval
95% CI 0.124-0.881
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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