Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling
2011
Cellular Interplay in Cardiac Remodeling
publication
Author Information
Author(s): Takeda Norifumi, Manabe Ichiro
Primary Institution: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Hypothesis
The study investigates the roles of nonmyocytes in cardiac remodeling and their communication with cardiomyocytes.
Conclusion
Nonmyocytes play crucial roles in cardiac remodeling processes, which share similarities with chronic inflammatory responses.
Supporting Evidence
- Cardiac hypertrophy involves complex structural remodeling.
- Nonmyocytes actively participate in the myocardial response to stress.
- Fibroblasts play a central role in cardiac fibrosis.
Takeaway
The heart has different types of cells that work together to help it adapt to stress, but sometimes this can lead to problems like heart failure.
Digital Object Identifier (DOI)
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