Biological Activities of Triclocarban and Triclosan in Bioassays
Author Information
Author(s): Ahn Ki Chang, Zhao Bin, Chen Jiangang, Cherednichenko Gennady, Sanmarti Enio, Denison Michael S., Lasley Bill, Pessah Isaac N., Kültz Dietmar, Chang Daniel P.Y., Gee Shirley J., Hammock Bruce D.
Primary Institution: University of California, Davis
Hypothesis
This study assesses the biological activities of triclocarban (TCC), its analogs, and triclosan (TCS) in various in vitro bioassays.
Conclusion
Triclocarban enhances hormone-dependent gene expression while triclosan exhibits antagonistic activity, suggesting potential implications for human and animal health.
Supporting Evidence
- Triclocarban enhanced estradiol-dependent gene expression by up to 2.5-fold.
- Triclosan exhibited antagonistic activity in both estrogen and androgen receptor bioassays.
- Triclosan significantly increased binding of ryanodine to RyR1 and elevated cytosolic calcium levels.
Takeaway
This study looked at how two common chemicals in soaps, triclocarban and triclosan, affect our bodies. Triclocarban can make hormones work better, while triclosan can block them.
Methodology
The study used in vitro nuclear-receptor-responsive and calcium signaling bioassays to assess the biological activities of TCC, its analogs, and TCS.
Potential Biases
Potential bias may arise from the selection of compounds and the specific bioassay methods used.
Limitations
The study primarily focuses on in vitro assays, which may not fully represent in vivo effects.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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