Impact of Cold Preservation Time on Lung Injury After Liver Transplantation
Author Information
Author(s): Jiang An, Liu Chang, Song Yulong, Liu Feng, Li Quanyuan, Wu Zheng, Yu Liang, Lv Yi
Primary Institution: Xi'an Jiaotong University
Hypothesis
Prolonged cold preservation time of donor liver induces liver damage and activates inflammatory factors that lead to acute lung injury.
Conclusion
Extended cold preservation time aggravates liver damage and induces inflammatory factors that migrate to the lung, ultimately causing acute lung injury.
Supporting Evidence
- Liver damage and acute lung injury increased significantly with prolonged cold preservation time.
- Inflammatory markers TNF-α and IL-1β increased in liver and serum with longer preservation times.
- The NF-κB inhibitor PDTC reduced liver and lung injury markers.
Takeaway
Keeping donor livers too long in cold storage can hurt the liver and cause problems in the lungs after a transplant.
Methodology
Wistar rats were used to create liver transplantation models, and the effects of different cold preservation times on liver and lung injury were measured.
Limitations
The study was conducted on rats, which may not fully replicate human responses.
Participant Demographics
Male Wistar rats, 272±31 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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