p21/WAF1 Expression in Colorectal Cancer and Its Prognostic Value
Author Information
Author(s): Ropponen K M, Kellokoski J K, Lipponen P K, Pietiläinen T, Eskelinen M J, Alhava E M, Kosma V-M
Primary Institution: Department of Pathology and Forensic Medicine, University of Kuopio
Hypothesis
The study investigates the relationship between p21/WAF1 expression and p53, AP-2 expressions, and their association with prognosis in colorectal carcinoma patients.
Conclusion
The study found that p21 expression levels can help predict the outcomes for colorectal cancer patients.
Supporting Evidence
- p21 expression was moderate or intense in 33% of the tumors.
- 53% of the tumors had moderate or strong p53 staining intensity.
- 89% of the tumors showed a weak cytoplasmic AP-2 signal.
- p21 and p53 stainings were inversely related to each other.
- There was a significant positive association between p21 and AP-2 expression levels.
- p21 intensity and percentage were higher in Dukes' A and B stages.
- Patients with low p21 signal had significantly lower cancer-related survival rates.
- High p53 staining intensity predicted poor survival.
Takeaway
This study looked at a protein called p21 in cancer patients to see if it could help doctors understand how well patients might do after treatment.
Methodology
The study assessed p21 expression in colorectal carcinoma patients and its relation to p53 and AP-2 expressions, as well as survival outcomes.
Participant Demographics
Patients with colorectal carcinoma.
Statistical Information
P-Value
P < 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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