Inhibition of angiogenesis and tumour growth by VEGF121–toxin conjugate: differential effect on proliferating endothelial cells
2000
Inhibition of Tumor Growth by VEGF121-Toxin Conjugate
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Wild R, Dhanabal M, Olson T A, Ramakrishnan S
Primary Institution: SUGEN Inc
Hypothesis
Can the VEGF121 isoform be used to target toxin polypeptides to tumor vasculature without causing toxicity?
Conclusion
The VEGF121-toxin conjugate effectively inhibited tumor growth and angiogenesis without apparent toxicity.
Supporting Evidence
- VEGF121-diphtheria toxin conjugate selectively inhibited proliferating endothelial cells.
- The treatment completely prevented tumor cell induced angiogenesis in vivo.
- The conjugate inhibited tumor growth in athymic mice.
- There was no apparent toxicity associated with the treatment.
Takeaway
This study found that a special protein can help deliver a toxin to cancer cells without hurting normal cells.
Methodology
The study involved treating endothelial cells with a VEGF121-diphtheria toxin conjugate and observing its effects on tumor growth in athymic mice.
Participant Demographics
Athymic mice were used in the study.
Digital Object Identifier (DOI)
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