Effect of Temperature on Carrageenan-Based Buccal Films
Author Information
Author(s): Kristó Katalin, Sangestani Anahita, Hassan Alharith A. A., Rayya Hala, Pamlényi Krisztián, Kelemen András, Csóka Ildikó
Primary Institution: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Hungary
Hypothesis
The study aims to optimize the process parameters during the production of carrageenan buccal films, particularly focusing on the effect of temperature.
Conclusion
Films made from 1.5% carrageenan and 1.5% glycerine at 70 °C are suitable for drug delivery on the buccal mucosa.
Supporting Evidence
- Glycerine reduces the mucoadhesivity and breaking hardness of the films.
- Increasing temperature makes the films more brittle.
- Statistical analysis confirmed the significance of carrageenan and glycerine concentrations on film properties.
- FTIR results showed no structural changes when glycerine was added.
Takeaway
This study looks at how temperature affects the making of thin films that can deliver medicine in the mouth, finding that a specific mix works best.
Methodology
Carrageenan was used as a polymer with glycerine as a plasticizer, and films were characterized using various analytical techniques.
Limitations
The study does not address the long-term stability of the films or their performance in real-world conditions.
Digital Object Identifier (DOI)
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