Grey Matter Patterns and Mobility in Older Adults
Author Information
Author(s): Wagshul Mark
Primary Institution: Albert Einstein College of Medicine
Hypothesis
The study aims to identify brain patterns of cortical grey matter associated with walking performance in older adults with and without multiple sclerosis.
Conclusion
The analysis of grey matter patterns can differentiate mobility control mechanisms in older adults with and without multiple sclerosis.
Supporting Evidence
- The first two principal components showed a significant association with single-task walking performance.
- PC1 was associated with single-task walking in healthy controls just below significance.
- PC2 was associated with single-task walking in MS participants.
Takeaway
Researchers looked at brain scans of older people to see how their brain structure affects their ability to walk, especially comparing those with and without multiple sclerosis.
Methodology
Cortical volume was measured using T1-weighted MRI images and Freesurfer software, along with gait assessments during single- and dual-task walking.
Participant Demographics
97 participants with multiple sclerosis and 105 healthy older adults.
Statistical Information
P-Value
p=0.0052
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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