Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers
2001
APC Gene Changes in Breast Cancer
Sample size: 50
publication
Evidence: moderate
Author Information
Author(s): Jin Z, Tamura G, Tsuchiya T, Sakata K, Kashiwaba M, Osakabe M, Motoyama T
Primary Institution: Yamagata University School of Medicine
Hypothesis
Is APC gene promoter hypermethylation involved in breast carcinogenesis?
Conclusion
APC promoter hypermethylation is a cancer-specific change in primary breast cancers.
Supporting Evidence
- Hypermethylation of the APC promoter was found in 36% of primary breast cancers.
- No APC or β-catenin mutations were detected in the breast cancers studied.
- APC promoter hypermethylation was not found in non-cancerous breast tissue.
Takeaway
The study found that a specific change in the APC gene is more common in breast cancer than we thought.
Methodology
Investigated APC gene promoter methylation and mutations in primary breast cancers and non-cancerous tissue.
Limitations
No significant associations were found with various clinical factors.
Digital Object Identifier (DOI)
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