Timing of Breast Cancer Surgery in Pre-Menopausal Women
Author Information
Author(s): Anushka Chaudhry, Michael L Puntis, Panos Gikas, Kefah Mokbel
Primary Institution: St George's Hospital, University of London
Hypothesis
Does the timing of breast cancer surgery in pre-menopausal women affect clinical outcome?
Conclusion
Breast cancer surgery during the luteal phase in pre-menopausal women may be associated with better clinical outcomes, but the evidence is not consistent.
Supporting Evidence
- Breast cancer surgery during the luteal phase may improve disease-free survival.
- Studies show inconsistent results regarding the timing of surgery and clinical outcomes.
- Meta-analysis indicated a 15% increase in survival for surgeries during the luteal phase.
Takeaway
This study looks at whether the time of month when women have breast cancer surgery affects how well they do afterward. Some evidence suggests that surgery during a certain time might help, but it's not clear.
Methodology
The paper reviews existing literature and studies on the timing of breast cancer surgery in relation to the menstrual cycle.
Potential Biases
Potential bias due to reliance on self-reported menstrual cycle timing and variations in study design.
Limitations
Many studies were retrospective and relied on inaccurate hormonal status assessments.
Participant Demographics
Pre-menopausal women with breast cancer.
Statistical Information
P-Value
0.003
Confidence Interval
15% (+/- 4%)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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