Preventive Effects of Pine Bark Extract on Metabolic Disease in Mice
Author Information
Author(s): Shimada Tsutomu, Kosugi Mitsutaka, Tokuhara Daisuke, Tsubata Masahito, Kamiya Tomoyasu, Sameshima Mayu, Nagamine Rika, Takagaki Kinya, Miyamoto Ken-ichi, Aburada Masaki
Primary Institution: Research Institute of Pharmaceutical Sciences, Musashino University
Hypothesis
Can Pine bark extract (Flavangenol) prevent obesity and metabolic diseases in a mouse model of type II diabetes?
Conclusion
Pine bark extract effectively prevents weight gain and metabolic complications in obese diabetic mice fed a Western diet.
Supporting Evidence
- Flavangenol suppressed body weight increase in TSOD mice.
- Flavangenol reduced visceral and subcutaneous fat accumulation.
- Flavangenol improved insulin resistance and metabolic parameters.
- Flavangenol increased adiponectin levels and decreased TNF-α levels.
- Flavangenol inhibited lipid absorption in vivo and pancreatic lipase in vitro.
Takeaway
This study shows that a special pine bark extract can help mice with diabetes not get fatter and stay healthier.
Methodology
TSOD mice were fed a Western diet and treated with Flavangenol to assess its effects on obesity and metabolic disease features.
Limitations
The study was conducted on mice, which may not fully represent human metabolic responses.
Participant Demographics
Tsumura Suzuki Obese Diabetes (TSOD) mice, a model for type II diabetes.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website