Marine-derived polysaccharides: the potential agents against neurodegenerative diseases
2024

Marine Polysaccharides and Neurodegenerative Diseases

publication Evidence: moderate

Author Information

Author(s): Zhu Lin, Ren Yuqian, Zhang Shenghan, Guo Yunliang, Zong Jinbao, Liu Yingjuan

Primary Institution: Qingdao University

Hypothesis

Can marine-derived polysaccharides serve as potential therapeutic agents against neurodegenerative diseases?

Conclusion

Marine polysaccharides, particularly fucoidan and chitosan, show promise in inhibiting neurodegenerative disease progression through various mechanisms.

Supporting Evidence

  • Polysaccharides have antioxidant and anti-inflammatory properties that may help in treating neurodegenerative diseases.
  • Chitosan has been shown to enhance cognitive function and memory in animal studies.
  • Fucoidan can inhibit the formation of beta-amyloid, a key factor in Alzheimer's disease.

Takeaway

Marine polysaccharides from sea creatures can help protect our brain cells and might be used to treat diseases like Alzheimer's and Parkinson's.

Methodology

This review summarizes various studies on the effects of marine polysaccharides on neurodegenerative diseases.

Limitations

Much of the research is still in preclinical or early clinical stages, and more extensive human trials are needed.

Digital Object Identifier (DOI)

10.3389/fphar.2024.1506789

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