Lean Body Mass, Interleukin 18, and Metabolic Syndrome in Healthy Chinese
Author Information
Author(s): Sun Liang, Hu Frank B., Yu Zhijie, Li Huaixing, Liu Huaiyu, Wang Xiangdong, Yu Danxia, Wu Hongyu, Zhang Geng, Zong Geng, Liu Yong, Lin Xu
Primary Institution: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Hypothesis
How is lean body mass related to circulating Interleukin 18 and its association with metabolic syndrome among apparently healthy Chinese?
Conclusion
Elevated plasma IL-18 was associated with higher metabolic syndrome prevalence in apparently healthy Chinese, independent of traditional risk factors.
Supporting Evidence
- Circulating IL-18 was positively correlated with lean mass index after adjustment for fat mass index.
- The odds ratio for metabolic syndrome was 3.43 in the highest quartile of IL-18 compared to the lowest.
- The association between IL-18 and metabolic syndrome was independent of traditional risk factors.
Takeaway
This study found that higher levels of a protein called IL-18 in the blood are linked to a higher chance of having metabolic syndrome, even in healthy people.
Methodology
A population-based sample of 1059 Chinese men and women aged 35–54 years was analyzed for plasma IL-18 and metabolic syndrome components.
Potential Biases
Potential biases due to self-reported data and the exclusion of individuals with acute inflammation.
Limitations
The cross-sectional design limits causal inferences, and the study may not be generalizable to all populations.
Participant Demographics
Chinese men and women aged 35–54 years, with 559 overweight/obese and 500 normal-weight participants.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 2.01–5.85
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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