Paeoniae alba Radix and Nerve Regeneration
Author Information
Author(s): Huang Kun-Shan, Lin Jaung-Geng, Lee Han-Chung, Tsai Fuu-Jen, Bau Da-Tian, Huang Chih-Yang, Yao Chun-Hsu, Chen Yueh-Sheng
Primary Institution: China Medical University, Taiwan
Hypothesis
Does Paeoniae alba Radix promote peripheral nerve regeneration?
Conclusion
Paeoniae alba Radix significantly enhances nerve regeneration and growth in peripheral nerves.
Supporting Evidence
- The PR extract significantly enhanced NGF-induced neurite outgrowth from PC12 cells.
- 86% of rats treated with 1.25 and 12.5 mg/ml of PR had regenerated nerve cables across a 10-mm gap.
- PR treatment increased the expression of GAP-43 and synapsin I in PC12 cells.
- Regenerated nerves in PR groups had larger total nerve area and myelinated axon counts compared to controls.
- NCV was significantly larger in the PR-treated group at 1.25 mg/ml compared to controls.
Takeaway
This study shows that a plant called Paeoniae alba Radix can help nerves heal better after being injured.
Methodology
The study involved in vitro and in vivo experiments using PC12 cells and silicone rubber chambers in rats to evaluate nerve regeneration.
Limitations
The high dose of PR (125 mg/ml) inhibited nerve regeneration, indicating a potential adverse effect at elevated concentrations.
Participant Demographics
Adult Sprague-Dawley rats were used in the in vivo study.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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