Helios as a Marker of T Cell Activation
Author Information
Author(s): Akimova Tatiana, Beier Ulf H., Wang Liqing, Levine Matthew H., Hancock Wayne W.
Primary Institution: The Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine
Hypothesis
Helios expression is associated with T cell activation and proliferation.
Conclusion
Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions.
Supporting Evidence
- Helios expression is associated with T cell activation and cellular division.
- Helios-negative T cells are enriched for naïve T cell phenotypes.
- Helios can be induced during T cell activation and proliferation.
Takeaway
Helios is a marker that shows when T cells are active and dividing, but it doesn't help tell apart different types of regulatory T cells.
Methodology
The study used flow cytometric analysis to assess Helios expression in human and murine T cells under various conditions.
Limitations
The study does not establish a clear distinction between natural and induced Tregs based on Helios expression.
Digital Object Identifier (DOI)
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