Norgestrel and Gestodene Stimulate Breast Cancer Cell Growth
Author Information
Author(s): W.H. Catherino, M.H. Jeng, V.C. Jordan
Primary Institution: University of Wisconsin Comprehensive Cancer Center
Hypothesis
Do the 19-norprogestins norgestrel and gestodene possess oestrogen-like activity in stimulating breast cancer cell growth?
Conclusion
Norgestrel and gestodene stimulate MCF-7 breast cancer cell growth by activating the oestrogen receptor.
Supporting Evidence
- Norgestrel and gestodene stimulated MCF-7 cell proliferation at concentrations achievable during oral contraceptive use.
- The stimulatory activity of the 19-norprogestins could be blocked by the antioestrogen ICI 164,384.
- MPA did not stimulate MCF-7 cell proliferation at any concentration tested.
Takeaway
Some birth control pills can make breast cancer cells grow faster, which is important to know for women's health.
Methodology
The study involved examining the proliferation of MCF-7 cells in culture with norgestrel, gestodene, and medroxyprogesterone acetate, along with transfection studies to assess intracellular actions.
Limitations
The study does not specify the long-term effects of these findings on actual breast cancer incidence in women.
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