Method for Measuring Paracetamol and Lornoxicam in Tablets
Author Information
Author(s): Shah Dimal A., Patel Neel J., Baldania Sunil L., Chhalotiya Usman K., Bhatt Kashyap K.
Primary Institution: Indukaka Ipcowala College of Pharmacy
Hypothesis
A stability indicating liquid chromatographic method can be developed for the simultaneous estimation of paracetamol and lornoxicam in combined dosage form.
Conclusion
The developed method is accurate, precise, and can effectively estimate paracetamol and lornoxicam in tablet form.
Supporting Evidence
- The method showed linearity for paracetamol and lornoxicam over specified concentration ranges.
- The accuracy of the method was confirmed with recovery rates between 97.28% and 100.34% for lornoxicam.
- The method demonstrated good precision with low relative standard deviation values.
- Forced degradation studies indicated that lornoxicam is stable under various conditions.
Takeaway
Researchers created a new way to measure two medicines in a tablet, making sure it works well and gives correct results.
Methodology
A reversed phase high performance liquid chromatographic method was developed and validated for the simultaneous determination of paracetamol and lornoxicam.
Digital Object Identifier (DOI)
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