TNF-alpha and Mesenchymal Precursors in Obese Mice
Author Information
Author(s): Gálvez Beatriz G., San Martín Nuria, Rodríguez Carlos, Polidori Carlo
Primary Institution: Projech Science to Technology, Madrid, Spain
Hypothesis
Does TNF-alpha play a role in attracting mesenchymal precursors to adipose tissue in ob/ob mice?
Conclusion
The study concludes that TNF-alpha is necessary for the migration of mesenchymal precursors to adipose tissue in ob/ob mice.
Supporting Evidence
- Ob/ob mice show a significant decrease in mesenchymal precursors in various tissues.
- Injected mesenchymal precursors migrate primarily to the adipose tissue in ob/ob mice.
- TNF-alpha levels are elevated in the adipose tissue of ob/ob mice, facilitating mesenchymal precursor migration.
Takeaway
In obese mice, a special type of cell called mesenchymal precursors moves to fat tissue, and this movement is helped by a substance called TNF-alpha.
Methodology
The study involved isolating mesenchymal precursors from various tissues of ob/ob and wild type mice and assessing their migration and differentiation.
Limitations
The study primarily focuses on ob/ob mice, which may limit the generalizability of the findings to other models of obesity.
Participant Demographics
The study used ob/ob mice, which are genetically modified to lack leptin, leading to obesity.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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