Surfactant Protein B Gene Variations and Lung Cancer Risk
Author Information
Author(s): Seifart C, Seifart U, Plagens A, Wolf M, von Wichert P
Primary Institution: Philipps-University of Marburg
Hypothesis
Surfactant protein gene variants may be related to an increased risk for developing lung cancer.
Conclusion
The study found that variations in the surfactant protein B gene are associated with an increased susceptibility to squamous cell carcinoma of the lung.
Supporting Evidence
- The frequency of the intron 4 variation was increased in lung cancer patients compared to controls.
- 25.0% of patients with squamous cell carcinoma had the gene variation.
- The study included a diverse group of lung cancer patients and healthy individuals.
Takeaway
Some people have changes in a gene that makes a protein important for lung health, and these changes might make them more likely to get a type of lung cancer.
Methodology
A matched case-control study analyzing a polymorphism within intron 4 of the surfactant protein B gene in lung cancer patients and controls.
Limitations
The study's control group was younger than the patient group, which may affect the results.
Participant Demographics
357 Caucasian individuals, including 117 lung cancer patients and 123 healthy individuals.
Statistical Information
P-Value
0.016
Confidence Interval
95%CI=1.24–8.28
Statistical Significance
p=0.016
Digital Object Identifier (DOI)
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