Losartan Rejuvenates Metabolome in Aged Mice
Author Information
Author(s): Bene Michael, Marx Ruth, Powell Laura, Ferrucci Luigi, Khadeer Mohammed, Moaddel Ruin, Rudek Michelle, Walston Jeremy
Primary Institution: Johns Hopkins University
Hypothesis
Can losartan reduce frailty risk and improve physical function in older adults through specific metabolic changes?
Conclusion
Losartan treatment in aged mice leads to a more youthful serum and heart metabolome, which is associated with improved survival.
Supporting Evidence
- Aged mice treated with losartan showed a global shift towards a more youthful serum metabolome.
- Losartan's effect on the heart may be partially AT1 dependent.
- AT2KO mice also displayed more youthful metabolomes when treated with losartan.
Takeaway
Giving older mice a medicine called losartan makes their blood and heart chemistry look more like younger mice, helping them live longer.
Methodology
Targeted metabolomics was performed on serum and heart samples from young and aged mice treated with losartan.
Participant Demographics
Young (4 months) and aged (24-28 months) mice were used in the study.
Statistical Information
P-Value
p=0.01; p=3.6e-8; p=0.015
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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