Postmenopausal Oestrogens and Endometrial Cancer Risk
Author Information
Author(s): Zeleniuch-Jacquotte A, Akhmedkhanov A, Kato I, Koenig K L, Shore R E, Kim M Y, Levitz M, Mittal K R, Raju U, Banerjee S, Toniolo P
Primary Institution: New York University School of Medicine
Hypothesis
Does higher serum levels of oestrogens and SHBG in postmenopausal women increase the risk of endometrial cancer?
Conclusion
Higher levels of postmenopausal oestrogens are associated with an increased risk of endometrial cancer.
Supporting Evidence
- 57 cases of endometrial cancer were diagnosed a median of 5.5 years after blood donation.
- Endometrial cancer risk increased with higher levels of oestradiol and oestrone.
- Risk decreased with higher levels of percent SHBG-bound oestradiol and SHBG.
Takeaway
This study found that women who have higher levels of certain hormones after menopause are more likely to get a type of cancer called endometrial cancer.
Methodology
A case-control study nested within the NYU Women's Health Study cohort comparing 57 cases of endometrial cancer to 4 matched controls.
Limitations
The study may not account for all potential confounding factors.
Participant Demographics
Postmenopausal women enrolled in the NYU Women's Health Study.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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