P-glycoprotein Dysfunction Leads to Obesity in Mice
Author Information
Author(s): Foucaud-Vignault Magali, Soayfane Zeina, Ménez Cécile, Bertrand-Michel Justine, Martin Pascal Guy Pierre, Guillou Hervé, Collet Xavier, Lespine Anne
Primary Institution: UMR1331, INP, UPS, TOXALIM, INRA, Toulouse, France
Hypothesis
Does P-glycoprotein deficiency affect lipid homeostasis and contribute to obesity in mice?
Conclusion
P-glycoprotein deficiency in mice leads to obesity and metabolic disorders, including hepatic steatosis.
Supporting Evidence
- P-glycoprotein deficient mice showed significant weight gain compared to wild-type mice.
- Insulin and glucose levels were higher in P-glycoprotein deficient mice.
- Hepatic steatosis was observed in P-glycoprotein deficient mice.
- Changes in lipid metabolism were linked to the absence of P-glycoprotein.
- High-fat diet exacerbated the obesity phenotype in P-glycoprotein deficient mice.
Takeaway
Mice without a protein called P-glycoprotein got really fat and had health problems because their bodies couldn't handle fats properly.
Methodology
The study involved feeding wild-type and P-glycoprotein deficient mice a standard chow diet and measuring their body weight, food intake, and various metabolic parameters over 35 weeks.
Potential Biases
Potential bias due to the specific genetic background of the mice used in the study.
Limitations
The study was conducted only in mice, which may not fully represent human physiology.
Participant Demographics
Mice were of the FVB genetic background, with both male and female subjects included.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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