Role of mTOR in T Cell Migration
Author Information
Author(s): Munk Rachel, Ghosh Paritosh, Ghosh Manik C., Saito Takeshi, Xu Mai, Carter Arnell, Indig Fred, Taub Dennis D., Longo Dan L.
Primary Institution: National Institute on Aging, National Institutes of Health
Hypothesis
The study investigates the role of mTOR in CXCL12-mediated T cell migration.
Conclusion
The study demonstrates that mTOR plays a significant role in CXCL12-induced T cell migration.
Supporting Evidence
- Rapamycin significantly inhibits CXCL12 mediated migration of T cells.
- p70S6K1 knockdown in T cells shows reduced migration in response to CXCL12.
- In vivo studies demonstrate reduced T cell migration in SCID mice with p70S6K1 knockdown.
Takeaway
This study shows that a protein called mTOR helps T cells move towards a signal that tells them where to go, which is important for fighting infections.
Methodology
The study used human T cells and a leukemia cell line to assess the effects of rapamycin on CXCL12-induced migration.
Participant Demographics
Healthy donors provided blood samples for T cell isolation.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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