Determining Oestrogen Receptors in Breast Cancer
Author Information
Author(s): A. Marrazzo, G. La Bara, P. Taormina, P. Bazan
Primary Institution: Clinica Chirurgica III e Centro Interdipartimentale di Ricerca in Oncologica Clinica, Universita di Palermo
Hypothesis
Can fine needle aspiration using monoclonal antibodies accurately determine oestrogen receptors in breast carcinoma?
Conclusion
The immunocytochemical method for determining oestrogen receptors in breast cancer is highly accurate and correlates well with traditional biochemical methods.
Supporting Evidence
- The immunocytochemical method showed 100% sensitivity and 88.2% specificity.
- Correlation coefficient between immunocytochemical and biochemical methods was 0.83.
- Immunocytochemical method demonstrated 95.6% accuracy.
Takeaway
Doctors can use a small needle to take samples from breast tumors to check for hormone receptors, which helps decide the best treatment.
Methodology
Fine needle aspiration was performed on 50 patients, and the samples were analyzed using immunocytochemical methods and compared with traditional biochemical techniques.
Limitations
Four cases could not be assessed due to insufficient cell numbers in the samples.
Participant Demographics
Patients aged 29 to 74 years, average age 59.2, with primary operable breast carcinoma.
Statistical Information
P-Value
p<0.000006
Statistical Significance
p<0.000006
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