Evaluating the LDH/Albumin Ratio in Adult-Onset Still’s Disease
Author Information
Author(s): Ekin Ali, Mısırcı Salim, Öztop Hikmet, Hacımustafaoğlu Asuman Şebnem, Coşkun Belkıs Nihan, Yağız Burcu, Dalkılıç Ediz, Pehlivan Yavuz
Primary Institution: Bursa Uludag University
Hypothesis
Can the lactate dehydrogenase-to-albumin ratio (LAR) effectively diagnose adult-onset Still’s disease compared to other inflammatory indices?
Conclusion
The LDH/Albumin ratio can help differentiate adult-onset Still’s disease patients from those with fever of unknown origin, but it has lower specificity than most other indices.
Supporting Evidence
- LAR had a sensitivity of 76.90% and a specificity of 48.60%.
- The highest specificity was found in LAR + ferritin (92.90%).
- Significant statistical differences were observed for all indices except CAR (p = 0.133).
- The study included 78 AOSD patients and 70 FUO patients.
Takeaway
This study looked at a blood test ratio to see if it can help doctors tell if someone has a specific disease called adult-onset Still’s disease, and found it can help but isn't the best option.
Methodology
A retrospective evaluation of 182 patients, comparing 78 with adult-onset Still’s disease and 70 with fever of unknown origin, using ROC analysis for diagnostic performance.
Potential Biases
The inclusion of a heterogeneous control group may have introduced confounding effects.
Limitations
The study was conducted at a single center, was retrospective, and had a small sample size.
Participant Demographics
The AOSD group had a mean age of 48.82 years, with 67.90% female participants.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI, 0.485–0.676
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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