Pharm Analysis and QAA Validated Densitometric Method for Analysis of Atorvastatin Calcium and Metoprolol Tartarate as Bulk Drugs and In Combined Capsule Dosage Forms
2011
Method for Analyzing Atorvastatin Calcium and Metoprolol Tartarate
publication
Evidence: high
Author Information
Author(s): SM Patole, AS Khodke, LV Potale, MC Damle
Primary Institution: A.I.S.S.M.S. College of Pharmacy, Pune, India
Hypothesis
A new high-performance thin-layer chromatographic method can accurately estimate Atorvastatin Calcium and Metoprolol Tartarate in combined capsule dosage forms.
Conclusion
The developed HPTLC method is sensitive, accurate, precise, simple, and rapid for estimating Atorvastatin Calcium and Metoprolol Tartarate.
Supporting Evidence
- The method was validated according to ICH guidelines.
- Linearity was established for both drugs in the range of 500 to 2500 ng/spot.
- Excellent recovery rates were achieved, indicating high accuracy.
- The method showed good precision with RSD values less than 1.5%.
- Specificity was confirmed through peak purity studies.
Takeaway
Researchers created a new way to measure two heart medications in a pill, making it easier to check how much of each is in there.
Methodology
The method used high-performance thin-layer chromatography with specific solvents and conditions to separate and measure the drugs.
Digital Object Identifier (DOI)
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