Effects of Cortical Spreading Depolarization on Brain Connectivity
Author Information
Author(s): Lachinova Daria A., Smirnova Maria P., Pavlova Irina V., Sysoev Ilya V., Vinogradova Lyudmila V.
Primary Institution: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
Hypothesis
Cortical spreading depolarization (CSD) increases intracortical inhibition, affecting interhemispheric functional connectivity.
Conclusion
CSD leads to a temporary loss of functional connectivity between the two hemispheres, which is influenced by GABAergic inhibition.
Supporting Evidence
- CSD causes a reversible loss of functional connectivity between the affected and unaffected cortices.
- The driving force from the unaffected cortex to the affected one increases after CSD.
- Pharmacological blockade of GABA(A) receptors alters the connectivity changes induced by CSD.
- Connectivity changes were consistent across individual animals, suggesting a potential biomarker for CSD.
Takeaway
When one side of the brain gets a temporary shock, it can stop talking to the other side for a little while, but this can be helped by certain chemicals in the brain.
Methodology
The study used local field potential recordings from the frontal cortex of rats to analyze functional connectivity before and after inducing CSD.
Potential Biases
Potential bias may arise from the specific conditions under which the experiments were conducted, including the use of pharmacological agents.
Limitations
The study was conducted on a small sample size of rats, which may limit the generalizability of the findings.
Participant Demographics
Male Wistar rats aged 3-4 months, weighing 285-400 g.
Statistical Information
P-Value
p<0.0003
Statistical Significance
p<0.0003
Digital Object Identifier (DOI)
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