The Autonomic Nervous System and Immune System in People with HIV
Author Information
Author(s): Mueller Bridget R, Mehta Mitali, Campbell Maya, Neupane Niyati, Cedillo Gabriela, Lee Gina, Coyle Kaitlyn, Qi Jinging, Chen Zhihong, George Mary Catherine, Robinson-Papp Jessica
Hypothesis
Are there connections between the peripheral autonomic nervous system and immune system in humans that contribute to chronic inflammatory disease?
Conclusion
Deficits in the parasympathetic and sympathetic nervous systems are linked to inflammation and disease burden in people living with HIV.
Supporting Evidence
- Reduced baroreflex sensitivity predicted higher levels of IL-6.
- A pro-inflammatory immunotype was associated with autonomic neuropathy characterized by deficits in sympathetic nervous system activity.
- The pro-inflammatory immunotype was older with a greater burden of co-morbidities.
Takeaway
This study found that problems with the nervous system can lead to more inflammation and health issues in people with HIV.
Methodology
79 adults with well-controlled HIV underwent autonomic function tests and immune biomarker measurements.
Participant Demographics
Adult people with well-controlled HIV.
Statistical Information
P-Value
p=0.002
Statistical Significance
p=0.002
Digital Object Identifier (DOI)
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