Rotavirus P[4]G2 in a Vaccinated Population, Brazil
Author Information
Author(s): Patel Manish M., Helena de Oliveira Lucia, Bispo Ana Maria, Gentsch Jon, Parashar Umesh D.
Primary Institution: Centers for Disease Control and Prevention
Hypothesis
Is the predominance of rotavirus P[4]G2 strains in Brazil related to vaccination with the Rotarix vaccine?
Conclusion
The predominance of P[4]G2 strains after the introduction of the Rotarix vaccine may represent a natural shift unrelated to vaccination.
Supporting Evidence
- The P[4]G2 strain was detected in all 21 rotavirus-positive stool samples.
- Ongoing surveillance in other countries showed P[4]G2 was the predominant circulating strain.
- The study suggests a natural shift in rotavirus strains may be occurring.
Takeaway
This study looked at rotavirus in kids who got vaccinated and found a specific strain was still common, which might not be because of the vaccine.
Methodology
Postmarketing surveillance data analysis from a community in Brazil with vaccination coverage of 50%.
Limitations
Small sample size, short duration of surveillance, and lack of a comparison group.
Participant Demographics
Most children >12 months old were ineligible for vaccination.
Digital Object Identifier (DOI)
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