How PFOA Causes Liver Tumors in Rainbow Trout
Author Information
Author(s): Susan C. Tilton, Gayle A. Orner, Abby D. Benninghoff, Hillary M. Carpenter, Jerry D. Hendricks, Cliff B. Pereira, David E. Williams
Primary Institution: Oregon State University
Hypothesis
Can perfluorooctanoic acid (PFOA) promote liver tumors in rainbow trout without causing peroxisome proliferation?
Conclusion
PFOA enhances liver tumor development in rainbow trout through estrogenic signaling rather than peroxisome proliferation.
Supporting Evidence
- PFOA and DHEA treatments resulted in increased liver tumor incidence and multiplicity.
- Carcinogenesis was independent of peroxisome proliferation.
- PFOA induced estrogenic gene signatures in trout liver.
- CLOF showed no effect on tumor incidence.
- Histologic examination confirmed mixed carcinoma as the predominant tumor type.
Takeaway
This study found that a chemical called PFOA can make fish get liver tumors, but it does this in a different way than expected, not by making their cells grow bigger.
Methodology
Rainbow trout were fed diets containing PFOA for 30 weeks, and liver tumors were analyzed along with gene expression profiles.
Limitations
The study was conducted in a specific fish model, which may not fully represent human responses to PFOA.
Participant Demographics
Rainbow trout (Oncorhynchus mykiss) were used as the model organism.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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