Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing’s group
1999
Esthesioneuroblastoma is not part of Ewing's tumor group
Sample size: 5
publication
Evidence: moderate
Author Information
Author(s): Mezzelani A, Tornielli S, Minoletti F, Pierotti M A, Sozzi G, Pilotti S
Primary Institution: Istituto Nazionale per lo Studio e la Cura dei Tumori
Hypothesis
Is esthesioneuroblastoma a member of the primitive peripheral neuroectodermal tumour-Ewing’s group?
Conclusion
The study concludes that esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing’s group.
Supporting Evidence
- The study found no EWS gene rearrangements in the analyzed tumor specimens.
- Trisomy 8 was only found in one of the five cases analyzed.
- No expression of the Ewing sarcoma-associated MIC2 antigen was detected.
Takeaway
Esthesioneuroblastoma is a type of cancer that is different from Ewing's tumors, and the researchers found no evidence to link them.
Methodology
The study analyzed five esthesioneuroblastoma tumor specimens using various molecular techniques.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website