Cissus quadrangularis Extract Reduces Pain from Chemotherapy in Rats
Author Information
Author(s): Olga Feigni Youyi Marcelle, Marius Mbiantcha, William Yousseu Nana, Gonzal Tsafack Eric, Flore Djuichou Nguemnang Stephanie, Chrétien Noungoua Mbeugangkeng, Gisèle Atsafack Mboudem Lylie, Gilbert Ateufack
Primary Institution: University of Dschang, Cameroon
Hypothesis
The ethanolic extract of Cissus quadrangularis can alleviate vincristine-induced peripheral neuropathy in rats.
Conclusion
The study found that Cissus quadrangularis extract significantly reduces pain and biochemical markers associated with neuropathy in rats treated with vincristine.
Supporting Evidence
- The extract significantly inhibited hyperalgesia and allodynia in animals after vincristine administration.
- The extract decreased total calcium levels in the sciatic nerve.
- The extract increased GSH activity and levels of 5-HT and GABA in the brain and spinal cord.
- Vincristine administration increased oxidative stress markers, which were reduced by the extract.
Takeaway
This study shows that a plant called Cissus quadrangularis can help reduce pain caused by a cancer treatment in rats.
Methodology
Rats were treated with vincristine to induce neuropathy, followed by administration of Cissus quadrangularis extract and assessment of pain responses and biochemical markers.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Wistar rats, both male and female, weighing between 160 and 200 g.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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