The Ubiquitous Dermokine Delta Activates Rab5 Function in the Early Endocytic Pathway
2011
The Ubiquitous Dermokine Delta Activates Rab5 Function in the Early Endocytic Pathway
publication
Evidence: moderate
Author Information
Author(s): Emilie A. Leclerc, Leila Gazeilles, Guy Serre, Marina Jonca, Nathalie Jonca
Primary Institution: UMR 5165 “Epidermis Differentiation and Rheumatoid Autoimmunity Unit”, CNRS – University Toulouse III
Hypothesis
What is the role of the dermokine Dmknδ in the early endocytic pathway?
Conclusion
Dmknδ activates Rab5 function and is involved in early endosomal trafficking.
Supporting Evidence
- Dmknδ interacts with Rab5, a key player in the early endocytic pathway.
- Dmknδ expression leads to the formation of vesicles that colocalize with Rab5.
- Dmknδ does not modulate transferrin endocytosis or recycling kinetics.
Takeaway
Dmknδ is a protein that helps another protein called Rab5 work better, which is important for moving things into cells.
Methodology
Yeast two-hybrid screening and GST pull-down assays were used to identify interactions between Dmknδ and Rab5.
Digital Object Identifier (DOI)
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