Tranexamic Acid Reduces Inflammation in Heart Surgery
Author Information
Author(s): Jimenez Juan J, Iribarren Jose L, Lorente Leonardo, Rodriguez Jose M, Hernandez Domingo, Nassar Ibrahim, Perez Rosalia, Brouard Maitane, Milena Antonio, Martinez Rafael, Mora Maria L
Primary Institution: Hospital Universitario de Canarias
Hypothesis
Can tranexamic acid reduce the inflammatory response and vasoplegic shock after cardiopulmonary bypass surgery?
Conclusion
The use of tranexamic acid reduces the development of inflammation and vasoplegic shock after heart surgery.
Supporting Evidence
- 165 patients were studied, with 20.6% fulfilling inflammatory response criteria.
- The use of tranexamic acid was associated with a lower incidence of inflammatory response.
- In the randomized trial, the incidence of inflammatory response was 17% in the tranexamic acid group versus 42% in the placebo group.
Takeaway
This study found that giving a medicine called tranexamic acid during heart surgery helps keep patients from getting too inflamed and having low blood pressure afterwards.
Methodology
The study included a case control study and a randomized double-blind trial comparing tranexamic acid to placebo in patients undergoing elective cardiopulmonary bypass surgery.
Limitations
The study was interrupted due to adverse effects in the placebo group and had a small sample size in the randomized trial.
Participant Demographics
Caucasian adult patients scheduled for cardiac surgery.
Statistical Information
P-Value
0.047
Confidence Interval
95% CI 0.18 to 0.81
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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