Osteopontin Levels in Maternal Serum, Cord Blood, and Breast Milk in Gestational Diabetes
Author Information
Author(s): Küçükoğlu Keser Merve, Şahin Dilek, Yalçın Sıddika Songül
Primary Institution: Ankara Bilkent City Hospital
Hypothesis
OPN and ANGPTL8 levels will change in GDM-diagnosed mothers compared to those with a normal pregnancy course.
Conclusion
Maternal serum and breast milk OPN levels are higher in GDM patients, suggesting a link to metabolic changes associated with the condition.
Supporting Evidence
- Maternal serum OPN levels were significantly higher in the GDM group than in the control group.
- Breast milk OPN levels were also greater in the GDM group.
- There was a moderate correlation between cord OPN and maternal serum OPN.
Takeaway
This study found that mothers with gestational diabetes have higher levels of a protein called osteopontin in their blood and breast milk, which might be related to their condition.
Methodology
The study involved face-to-face interviews and biomarker measurements in 165 participants, comparing GDM and control groups.
Potential Biases
Potential bias due to dietary changes and insulin therapy affecting OPN levels.
Limitations
Maternal serum OPN was only measured at delivery, and ANGPTL8 levels in maternal serum were not assessed.
Participant Demographics
Mean age was 29.0 years in the control group and 31.4 years in the GDM group.
Statistical Information
P-Value
p=0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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