VEGF Expression in Lung Cancer
Author Information
Author(s): Fontanini G, Boldrini L, Chinè S, Pisaturo F, Basolo F, Calcinai A, Lucchi M, Mussi A, Angeletti C A, Bevilacqua G
Primary Institution: University of Pisa, Italy
Hypothesis
The study investigates the expression of vascular endothelial growth factor (VEGF) in non-small-cell lung carcinomas to evaluate its significance in cancer progression.
Conclusion
The study found that VEGF expression is associated with poor prognosis in non-small-cell lung carcinomas.
Supporting Evidence
- 78.6% of cases showed VEGF transcript expression.
- VEGF expression was associated with nodal involvement.
- VEGF isoforms significantly influenced overall survival.
Takeaway
This study looked at a substance called VEGF in lung cancer samples to see if it could help predict how the cancer would behave.
Methodology
Surgical samples from 42 patients were analyzed using reverse transcription polymerase chain reaction (PCR) and in situ hybridization.
Participant Demographics
Patients with non-small-cell lung carcinomas.
Statistical Information
P-Value
P = 0.02 for overall survival; P = 0.03 for disease-free survival.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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