Comparing HIV Treatment Regimens in Older Adults
Author Information
Author(s): Yan Lei, Henegar Cassidy E., Marconi Vincent C., Gordon Kirsha S., Hicks Charles, Vannappagari Vani, Justice Amy C., Aslan Mihaela
Primary Institution: Veterans Affairs (VA) Connecticut Healthcare System
Hypothesis
How do dolutegravir-based regimens compare to other antiretroviral regimens in older adults with HIV?
Conclusion
Dolutegravir-based regimens are more effective and durable than darunavir- or raltegravir-based regimens in older adults with HIV.
Supporting Evidence
- DTG-based regimens showed higher levels of effectiveness compared to DRV- or RAL-based regimens.
- ART-experienced individuals on RAL and DRV were less likely to achieve virologic suppression.
- Discontinuation rates were higher for those on RAL and DRV compared to DTG.
Takeaway
This study looked at older adults with HIV and found that those taking a specific medicine called dolutegravir did better than those taking other medicines.
Methodology
This cohort study analyzed data from older adults with HIV who were prescribed various antiretroviral therapy regimens and assessed their virologic effectiveness and regimen discontinuation.
Potential Biases
Potential residual confounding due to unmeasured variables and differences in demographics between veterans and the general population.
Limitations
The study may not be generalizable to non-veteran populations and lacked detailed documentation on reasons for regimen changes.
Participant Demographics
Median age 58-62 years; 94-98% male; 5-11% Hispanic; 44-60% Black; 29-42% White.
Statistical Information
Confidence Interval
95% CI 0.51–0.81; 95% CI 0.52–0.80
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website