Urinary Androgens and Breast Cancer Risk
Author Information
Author(s): Wang D Y, Allen D S, Stavola B L De, Fentiman I S, Brussen J, Bulbrook R D, Thomas B S, Hayward J L, Reed M J
Primary Institution: Unit of Metabolic Medicine, St Mary's Hospital Medical School, London, UK
Hypothesis
The study investigates the relationship between urinary androgen metabolites and breast cancer risk in women.
Conclusion
The study found that low levels of urinary androgen metabolites were associated with an increased risk of breast cancer in younger women, while older women showed a different pattern.
Supporting Evidence
- The cohort was followed for 37 years, with 248 women diagnosed with breast cancer.
- Low urinary androgen levels were linked to higher breast cancer risk in younger women.
- In older women, the relationship between androgen levels and breast cancer risk was reversed.
Takeaway
The study looked at how certain hormones in urine might affect the chances of getting breast cancer, finding that younger women with low hormone levels were at higher risk.
Methodology
A cohort of over 5000 women was followed for 37 years, measuring urinary androgen metabolites and tracking breast cancer diagnoses.
Participant Demographics
The study involved women, predominantly premenopausal in the younger age group and post-menopausal in the older age group.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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