HPV16E6 and c-Fos in Cervical Cancer Cells
Author Information
Author(s): Liang Feixin, Kina Shinichiro, Takemoto Hiroyuki, Matayoshi Akira, Phonaphonh Thongsavanh, Sunagawa Nao, Arakaki Keiichi, Arasaki Akira, Kuang Hai, Sunakawa Hajime
Primary Institution: University of Ryukyus
Hypothesis
Under oxidative stress, HPV16E6 function might contribute to c-fos expression and c-fos/c-jun heterodimer formation.
Conclusion
HPV16E6 is necessary for c-fos/c-jun heterodimer formation in cervical cancer cells under oxidative stress.
Supporting Evidence
- HPV16E6 contributes to AP-1 complex formation under oxidative stress.
- c-fos expression is induced by both H2O2 and TGF-α in SiHa cells.
- Inhibition of c-fos expression was observed with siRNA targeting HPV16E6.
Takeaway
The study found that a protein from HPV can help cancer cells grow by changing how they respond to stress.
Methodology
The study used SiHa cells and examined c-fos expression after treatment with H2O2 and TGF-α, along with siRNA transfection to assess the role of HPV16E6.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website