NAD+ Supplementation and Inflammation in Delirium
Author Information
Author(s): Chui M K, Kirsten Buck, Kumaar Prasanna Vadhana Ashok, Verdin Eric, Newman John
Primary Institution: Buck Institute for Research on Aging
Hypothesis
Does acute NAD+ supplementation help reduce inflammation in a mouse model of delirium?
Conclusion
Acute NAD+ supplementation can reduce certain inflammatory markers in aged mice but does not improve sickness behavior or metabolic dysfunction.
Supporting Evidence
- NAD+ supplementation did not improve sickness behavior in mice.
- NAD+ supplementation partially improved levels of certain cytokines.
- The effects of NAD+ supplementation were found to be sex dependent.
Takeaway
Giving NAD+ to mice with delirium helps lower some inflammation but doesn't make them feel better overall.
Methodology
The study used a mouse model of delirium induced by LPS and assessed the effects of NMN supplementation on cytokine levels.
Limitations
The study did not assess the effects of NAD+ on overall sickness behavior or metabolic dysfunction.
Participant Demographics
Aged mice were used in the study.
Digital Object Identifier (DOI)
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