Comparison of FRAX Scores for Mexican Descent Women in Southern California
Author Information
Author(s): Nasser Keaton M., Focil Augusto, Silverman Stuart L.
Primary Institution: Osteoporosis Medical Center
Hypothesis
Do FRAX estimates for Hispanic women in Southern California differ between the US Hispanic database and the Mexico database?
Conclusion
The comparison between the FRAX databases shows similar absolute risk for major osteoporotic fractures, but differences in hip fracture risk were noted.
Supporting Evidence
- The study included 134 women of Mexican descent from Southern California.
- The mean conformity for meeting the interventional threshold was 94.8%.
- The 10-year absolute risk of major osteoporotic fracture was similar between the two databases.
Takeaway
This study looked at how likely Hispanic women in Southern California are to have bone fractures, comparing two different databases. It found that both databases give similar results for major fractures, but different results for hip fractures.
Methodology
FRAX risk factor data was collected from 134 postmenopausal Hispanic women of Mexican descent in Southern California, and risk scores were calculated using both US Hispanic and Mexico databases.
Potential Biases
The US Hispanic database may underestimate fracture risk for Californian Hispanics due to its broader sampling.
Limitations
The study is limited to 134 subjects and does not determine which database more accurately reflects fracture risk.
Participant Demographics
Participants were postmenopausal Hispanic women over age 40, primarily of Mexican descent.
Statistical Information
P-Value
P = .94 for major osteoporotic fracture; P = .26 for hip fracture
Confidence Interval
95% CI 3.97–5.67 for major osteoporotic fracture using US database; CI 4.06–5.66 using Mexico database
Digital Object Identifier (DOI)
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