Role of Hypoxia Inducible Factors in Lung Cancer
Author Information
Author(s): Giatromanolaki A, Koukourakis M I, Sivridis E, Turley H, Talks K, Pezzella F, Gatter K C, Harris A L
Primary Institution: Democritus University of Thrace
Hypothesis
The study investigates the relationship between hypoxia inducible factors HIF1α and HIF2α and the angiogenic/molecular profile of tumors in non-small cell lung cancer.
Conclusion
HIF1α and HIF2α overexpression is common in non-small cell lung cancer and is associated with poor prognosis.
Supporting Evidence
- HIF1α was expressed in 62% of cases and HIF2α in 50%.
- HIF2α expression was related to poor overall survival.
- HIF1α expression was marginally associated with poor prognosis.
- HIF2α was an independent prognostic indicator.
Takeaway
This study found that two proteins, HIF1α and HIF2α, are often found in lung cancer and can help predict how bad the cancer might be.
Methodology
Immunohistochemical expression analysis of HIF1α and HIF2α in tissue samples from non-small-cell lung cancer and normal lung tissues.
Statistical Information
P-Value
P < 0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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