Ghrelin O-Acyl Transferase: Bridging Ghrelin and Energy Homeostasis
2011
Ghrelin O-Acyl Transferase and Energy Balance
publication
Evidence: moderate
Author Information
Author(s): A. Shlimun, S. Unniappan
Primary Institution: York University
Hypothesis
How does ghrelin O-acyl transferase (GOAT) influence energy homeostasis?
Conclusion
GOAT plays a critical role in the acylation of ghrelin, which is essential for regulating energy balance and metabolism.
Supporting Evidence
- GOAT is essential for the acylation of ghrelin, which is necessary for its biological activity.
- Studies show that GOAT expression is highest in the stomach and intestine.
- GOAT knockout mice lack acyl ghrelin and show altered energy balance.
- Modulating GOAT activity can influence body weight and insulin secretion.
Takeaway
GOAT is an important enzyme that helps modify a hormone called ghrelin, which tells our body when to eat and helps manage energy levels.
Methodology
The paper reviews various studies on GOAT's role in ghrelin acylation and its effects on metabolism.
Limitations
The research primarily focuses on animal models, and the implications for human metabolism remain uncertain.
Digital Object Identifier (DOI)
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