Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes
2010
Inhibition of O-GlcNAcase and Insulin Resistance
publication
Author Information
Author(s): M.S. Macauley, Y. He, T.M. Gloster, K.A. Stubbs, G.J. Davies, D.J. Vocadlo
Primary Institution: Simon Fraser University
Conclusion
The study found that inhibiting O-GlcNAcase does not lead to insulin resistance in 3T3-L1 adipocytes.
Supporting Evidence
- M.S.M., K.A.S., and D.J.V. are eligible to receive royalties from Simon Fraser University.
- G.J.D. is a member of the scientific advisory board of Alectos Therapeutics.
- D.J.V. is a founder, shareholder, consultant, and member of the scientific advisory board of Alectos Therapeutics.
Takeaway
The researchers looked at a way to block a specific enzyme and found it doesn't make fat cells resistant to insulin.
Digital Object Identifier (DOI)
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