Zweifel Olefination for C-Glycosylation

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Author Information

Author(s): Florian Trauner, Bilel Boutet, Fabian Pilz, Verena Weber, Didier Dorian

Primary Institution: Technische Universität Darmstadt

The study investigates the use of Zweifel olefination to selectively synthesize C-glycosides from unsaturated glycal derivatives.

The study demonstrates an efficient and selective method for synthesizing C-glycosides, which could be applied in drug discovery.

C-glycosides are more stable and bioavailable than O-glycosides, making them significant in medicinal chemistry.
The Zweifel olefination method allows for efficient synthesis of C-glycosides from glycal derivatives.
Optimized conditions led to moderate to high yields of various C-glycosides.
The method is applicable to different glycal derivatives, enhancing its utility in drug discovery.

This study shows a new way to make special sugar compounds that can help create better medicines.

The authors optimized metalation conditions and applied Zweifel olefination to synthesize various C-glycosides from glycal derivatives.

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