How Oestrogen Affects Resveratrol in Breast Cancer Cells
Author Information
Author(s): Zhang S, Cao H, Davis F B, Tang H-Y, Davis P J, Lin H-Y
Primary Institution: The Ordway Research Institute
Hypothesis
Does oestrogen inhibit the apoptosis induced by resveratrol in breast cancer cells?
Conclusion
Oestrogen inhibits resveratrol-induced apoptosis in breast cancer cells by interfering with the post-translational modifications of p53.
Supporting Evidence
- Resveratrol induced apoptosis in MCF-7 cells, but this effect was blocked by oestrogen.
- Oestrogen inhibited the phosphorylation and acetylation of p53, which are necessary for its activity.
- Using an oestrogen receptor inhibitor, the study showed that the effects of oestrogen on p53 were receptor-mediated.
- Resveratrol's ability to activate MAPK was enhanced by oestrogen, but this did not lead to increased apoptosis.
Takeaway
This study found that oestrogen stops a substance called resveratrol from making cancer cells die. It does this by changing a protein called p53 that helps control cell death.
Methodology
The study used MCF-7 breast cancer cells to examine the effects of resveratrol and oestrogen on p53 modifications and apoptosis through various assays.
Limitations
The study primarily focused on a single cell line, which may not represent all breast cancer types.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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